Medicine for Cholesterol

If you have high cholesterol or are at risk of cardiovascular disease, your doctor may prescribe a medicine. These drugs can help lower your LDL, or "bad," cholesterol and reduce the amount of triglycerides in your blood.

While statins are the most popular, there are also several other kinds of medicines that may be recommended. These are called nonstatin medications.

Statins

Cholesterol is a waxy substance in your blood that's necessary for cell and body function, as well as the manufacture of vitamin D and hormones. When your cholesterol levels are too high, they can cause a condition called atherosclerosis. This causes fatty, hardened areas to build up in your arteries (where your blood goes to your heart) and block the flow of blood.

Luckily, atherosclerosis can be controlled with healthy lifestyle changes like eating right, exercising and not smoking. But if these measures don't work, doctors may recommend statins to help prevent heart disease and stroke.

Statins lower your 'bad' cholesterol, which is LDL, and 'good' cholesterol, which is HDL. They also protect the insides of your arteries, making them less likely to get blocked and causing problems such as heart attacks or strokes.

While lowering your cholesterol with statins is one of the most effective ways to prevent CVD, they have to be taken along with other steps to reduce your risk. They're usually prescribed for people who have a history of heart or blood vessel disease, or who are at high risk of developing it in the future.

The drugs work by inhibiting an enzyme called HMG-CoA reductase in the liver that is needed to make cholesterol. When this enzyme is blocked, the liver doesn't produce as much cholesterol, so your blood cholesterol levels decrease.

Although they can cause some side effects, most people experience fewer than expected side effects when taking statins. These are typically mild, such as diarrhoea, headache and feeling sick.

If you are worried about the side effects of taking statins, talk to your doctor about the benefits and risks carefully. They can then offer a solution.

Alternatively, they can offer you a newer medication called a PCSK9 inhibitor. These are injected once or twice a month and work by blocking an enzyme (protein) that is needed for your body to break down LDL cholesterol.

As they are a relatively new class of medications, there's a lot more research to be done on their use and how they affect your health. However, for now, they are the most effective cholesterol-lowering medicines and can be a life-saving option for some people.

Cholesterol absorption inhibitors

Cholesterol absorption inhibitors are medicines for cholesterol that work by blocking the uptake of bile acid into the small intestine. These medications reduce LDL cholesterol and may also decrease triglycerides (a type of fat in the blood).

The goal is to lower LDL levels so that your body can make less plaque in your arteries. This reduces the risk of heart attacks and strokes. These drugs are usually used in combination with other lipid-lowering drugs, such as statins and fibrates.

Ezetimibe is a new medication that works in the intestine to stop your body from absorbing cholesterol. It lowers your LDL and triglyceride levels, while raising your HDL "good" cholesterol. It's a lipid-lowering drug that's mainly used for people with high cholesterol or those who don't respond to statins.

It's a medicine that you take orally, either by mouth or in capsule form. You'll need to drink three to four ounces of liquid with each dose, such as water, juice or noncarbonated beverage.

Your doctor will tell you how to take it. It's not safe to skip a dose or miss a scheduled dose, and you must remember to take it with your next meal. It's also not safe to take ezetimibe on an empty stomach or with other medications, such as calcium channel blockers and niacin.

You can't get ezetimibe if you have a history of liver disease or kidney problems, or if you are pregnant, breastfeeding, or trying to become pregnant. You should be careful taking it if you have high blood pressure, diabetes or if you are overweight.

This medication is a newer, more potent version of the cholesterol absorption cholesterol kam karny ka Unani ilaaj. It works by inhibiting a specific cholesterol transport protein called Niemann-Pick C1-like 1. The protein transports dietary and bile cholesterol, fatty acids and phytosterols in the small intestine.

It lowers LDL cholesterol and triglycerides in some people who are not getting enough LDL-lowering from other medications or who don't respond to statins. It's a drug that is becoming more popular because it can be used with statins. It can help to reduce the risk of heart attacks and strokes in certain patients with chronic kidney disease or other heart problems. It's also a good choice for people with FH who don't get the results they want from statin therapy alone.

Fibrates

Fibrates are a group of medicines used to reduce high cholesterol levels. They lower triglyceride levels, help increase HDL cholesterol levels and reduce the risk of heart disease and stroke. They are often prescribed along with statins.

The lipid-lowering effects of fibrates depend on their action on the PPAR alpha nuclear receptor. This receptor stimulates the expression of genes involved in triglyceride and HDL metabolism, resulting in reduced triglyceride synthesis, increased triglyceride catabolism and enhanced HDL production.

PPAR alpha activation also increases the transcription of apoA-I and apoA-II, which contribute to the formation of HDL. The increased production of these proteins results in greater HDL synthesis and may reduce the formation of triglyceride-rich lipoproteins (TG).

A randomized controlled trial demonstrated that gemfibrozil significantly reduced triglyceride concentrations in hyperlipidemic patients with hypertriglyceridemia. However, the study did not show a reduction in the incidence of cardiovascular events or death.

Another study showed that fenofibrate significantly decreased triglyceride concentrations in diabetic patients with metabolic syndrome. This drug is especially helpful in the treatment of patients with a high risk for developing diabetes, who are also at higher risk of coronary heart disease.

Fibrates also lower LDL cholesterol, although not as effectively as statins. Typically, a transliterated patient will have LDL cholesterol below 100 mg/dL.

In contrast, the use of a statin can lower LDL cholesterol to below 70 mg/dL, or sometimes to 50 mg/dL, depending on the type of underlying hyperlipidemia. The majority of people with hypercholesterolaemia should be treated with a statin to achieve their LDL goals, with other lipid-lowering therapies added as needed.

Several severe adverse reactions occur with fibrates, including elevated liver enzymes, decreased white blood cells and cholelithiasis, which occurs when bile secretion is increased. If a patient develops any of these symptoms, he or she should be monitored closely.

In recent years, prescriptions for fibrate drugs have increased in the castrol ka desi ilaj. While prescriptions have not yet exceeded prescriptions for the other lipid-lowering medications, they are expected to do so in the future.

PCSK9 inhibitors

PCSK9 inhibitors, sometimes referred to as monoclonal antibodies, are a new type of medicine for cholesterol. They are used to lower LDL cholesterol, which is known to increase your risk of heart disease. The medicine may be given alone or with another type of cholesterol-lowering drug, such as a statin.

The medicine works by inhibiting a protein called proprotein convertase subtilisin/kexin type 9 (PCSK9), which is made in the liver. People with high levels of this protein have a higher risk of heart disease, while people with low levels have a lower risk.

Inhibitors work by blocking PCSK9 from binding the LDL receptors that sweep excess cholesterol away from the blood. This causes more of these receptors to be active, which means that more cholesterol can be swept away and less can build up in the body.

There are two kinds of PCSK9 inhibitors, alirocumab and evolocumab. Both are injectable medications that are taken every 2 to 4 weeks in a medical facility.

Several studies have shown that these drugs reduce your risk of heart attack by up to 27%. However, they can cause some side effects, like muscle pain and flulike symptoms, so they are not for everyone.

Many doctors prescribe them to patients who have tried other treatment options, but their cholesterol is still high. They also can be prescribed to people with a genetic condition that causes high cholesterol levels.

When paired with other cholesterol-lowering treatments, these medications can be very effective at lowering your risk of heart disease and preventing strokes and other serious problems. Some research has even suggested that they may be helpful in reducing your risk of dying from heart disease, but the exact benefits aren't well understood yet.

If your doctor has recommended you use a cholesterol kam karne ki desi dawa, make sure to follow up regularly with your provider. They will let you know how well your medication is working and will check your blood if you need to.